Mark E. Smith formed The Fall (named after the novel by Camus) with friends after dropping out of college at the age of 19. He gave up his job at Salford docks shortly after to devote his full energies to The Fall, and has continued to do so ever since. Smith married Chicagoan guitarist (and Fall band member, 1983-89, 1994-96) Brix Smith on 19 July 1983, though they divorced in 1989. He has since remarried twice. He married his present wife, Eleni (sometimes called Elenor or Elena) Poulou, in 2001, and she joined The Fall in September 2002.
When British DJ and Fall champion John Peel died in 2004, Smith made a notorious appearance on the BBC’s Newsnight show. Regarded by many as a bewildering performance, Smith has made his appreciation for John Peel clear in several subsequent interviews. Nevertheless, the two only met a handful of times. Though he broke his hip while promoting the album The Real New Fall LP (Formerly Country on the Click) in 2004, Smith refused to cancel an upcoming American tour, instead choosing to perform in a wheelchair. Unfortunately the pain and medication caused a number of dates to be cancelled.
In January 2005, The Fall were the subject of The Fall: The Wonderful and Frightening World of Mark E. Smith, a BBC Four television documentary. The following August, Smith received the "Contribution to Music" award at the Diesel-U-Music Awards. Smith's autobiography, Renegade: The Gospel According to Mark E. Smith, recorded with Manchester-based writer Austin Collings, was published by Viking Books in April 2008. The latest studio album by The Fall, Your Future Our Clutter, was released on 26 April 2010.